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More events occur in patients with normal or mildly abnormal functional tests, as shown by latest analysis of PROMISE study.

UK NICE guidance recommends CT coronary angiography for diagnosis of CAD in patients with atypical or typical angina in its 2016 update of CG95 (Chest pain of recent onset: assessment and diagnosis).

Prospective multicentre trial aimed to investigate the use of CT coronary angiogram compared to standard care in patients with stable chest pain in terms of its affect on diagnosis, management and outcome of patients.

Total coverage of myocardium for stress perfusion has been limited with cardiovascular magnetic resonance technique (CMR).

These latest guidelines reveiw the use of diagnostic invasive coronary angiography and management in patients with stable ischemic heart disease.

Presence of transmural perfusion gradient was studied using [15O] H20 PET-CT in 66 patients with angina and correlated with FFR- determined severity.

An important study comparing CTA and combined CTA+CTP with SPECT MPI and invasive angiography.

This latest document rates the appropriateness of different imaging modalities for various indications to exclude stable ischemic heart disease.